In organic
chemistry, peptide synthesis is the production of peptides, compounds where
multiple amino acids are linked via amide bonds, also known as peptide bonds.
Peptides are chemically synthesized by the condensation reaction of the carboxyl
group of one amino acid to the amino group of another. Protecting group
strategies are usually necessary to prevent undesirable side reactions with the
various amino acid side chains. Chemical peptide synthesis most commonly starts
at the carboxyl end of the peptide (C-terminus), and proceeds toward the
amino-terminus (N-terminus). Protein
biosynthesis (long peptides) in living organisms occurs in the opposite
direction.
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