Supramolecular catalysis is not a
well-defined field but it generally refers to an application of supramolecular
chemistry, especially molecular recognition and guest binding, toward catalysisThis
field was originally inspired by enzymatic system which, unlike classical
organic chemistry reactions, utilizes non-covalent interactions such as
hydrogen bonding, cation-pi interaction, and hydrophobic forces to dramatically
accelerate rate of reaction and/or allow highly selective reactions to occur. Because
enzymes are structurally complex and difficult to modify, supramolecular
catalysts offer a simpler model for studying factors involved in catalytic
efficiency of the enzyme.[3]:1 Another goal that motivates this field is the
development of efficient and practical catalysts that may or may not have an
enzyme equivalent in nature.
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